Co-localization segments of human genome for Roadmap cell types

Description

A co-localization statistic is to identify individual (tissue/cell type specific) regulatory regions that are under sequence constraint. We employ a sliding-window type approach with window size 1 Kb, and 500 bps overlap, and for each such window we report a co-localization local fdr value. The UCSC Genome Browser Track Hub is provided to view the co-localized regulatory segments in the human genome assembly hg19 for 127 Roadmap cell types. There is an online spreadsheet with information about the 127 Roadmap cell types. The track displays co-localized regions which have local fdr < 0.3 in black segments.

Reference

Danqing Xu, Chen Wang, Krzysztof Kiryluk, Joseph D. Buxbaum, Iuliana Ionita-Laza, "Co-localization between sequence constraint and epigenomic information improves interpretation of whole genome sequencing data". Submitted.

More information can be found from our co-localization web server

Data Access

The raw data in the bigWig format for the tracks are available here

Contact

Please e-mail ii2135@cumc.columbia.edu or cw3154@cumc.columbia.edu with any questions or comments about this website and the track hub.