title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ94; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ94", "age": "30", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast carcinoma tissue FD27T; {"isolate": "carcinoma tissue, early breast cancer, HER2, FD27T", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200039, China", "sex": "female", "tissue": "breast"}
title: WGBS of early Luminal B subtype breast carcinoma tissue FD17T; {"isolate": "carcinoma tissue, early breast cancer, Luminal B, FD17T", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200037, China", "sex": "female", "tissue": "breast"}
title: WGBS of early Luminal B subtype breast pare-carcinoma tissue FD17N; {"isolate": "para-carcinoma tissue, early breast cancer, Luminal B, FD17N", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200036, China", "sex": "female", "tissue": "breast"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ88; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ88", "age": "55", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced HER2 subtype breast cancer ctDNA TZ85; {"isolate": "ctDNA, advanced breast cancer, HER2, TZ85", "age": "63", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ84; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ84", "age": "48", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early TNBC subtype breast cancer ctDNA TZ80; {"isolate": "ctDNA, early breast cancer, TNBC, TZ80", "age": "30", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ97; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ97", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ95; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ95", "age": "58", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0034; {"isolate": "ctDNA, health, N0034", "age": "43", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0028; {"isolate": "ctDNA, health, N0028", "age": "40", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0027; {"isolate": "ctDNA, health, N0027", "age": "38", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0026; {"isolate": "ctDNA, health, N0026", "age": "37", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0033; {"isolate": "ctDNA, health, N0033", "age": "58", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0032; {"isolate": "ctDNA, health, N0032", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0031; {"isolate": "ctDNA, health, N0031", "age": "35", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0029; {"isolate": "ctDNA, health, N0029", "age": "36", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast pare-carcinoma tissue FD27N; {"isolate": "para-carcinoma tissue, early breast cancer, HER2, FD27N", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200038, China", "sex": "female", "tissue": "breast"}
title: WGBS of healthy human cfDNA N0040; {"isolate": "ctDNA, health, N0040", "age": "24", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ69; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ69", "age": "62", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0041; {"isolate": "ctDNA, health, N0041", "age": "30", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0042; {"isolate": "ctDNA, health, N0042", "age": "27", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0043; {"isolate": "ctDNA, health, N0043", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0037; {"isolate": "ctDNA, health, N0037", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0039; {"isolate": "ctDNA, health, N0039", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0045; {"isolate": "ctDNA, health, N0045", "age": "65", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA XH23; {"isolate": "ctDNA, early breast cancer, Luminal A, XH23", "age": "66", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100036, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA XH21; {"isolate": "ctDNA, early breast cancer, HER2, XH21", "age": "48", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100035, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early TNBC subtype breast carcinoma tissue FD4T; {"isolate": "carcinoma tissue, early breast cancer, TNBC, FD4T", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200033, China", "sex": "female", "tissue": "breast"}
title: WGBS of early TNBC subtype breast pare-carcinoma tissue FD4N; {"isolate": "para-carcinoma tissue, early breast cancer, TNBC, FD4N", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200032, China", "sex": "female", "tissue": "breast"}
title: WGBS of early Luminal A subtype breast carcinoma tissue FD16T; {"isolate": "carcinoma tissue, early breast cancer, Luminal A, FD16T", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200035, China", "sex": "female", "tissue": "breast"}
title: WGBS of early Luminal A subtype breast pare-carcinoma tissue FD16N; {"isolate": "para-carcinoma tissue, early breast cancer, Luminal A, FD16N", "age": "missing", "biomaterial_provider": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; Shanghai Medical College; Key Laboratory of Breast Cancer in Shanghai; Innovation Center for Cell Signaling Network; Cancer Institutes, Fudan University, Shanghai, 200034, China", "sex": "female", "tissue": "breast"}
title: WGBS of early Luminal B her2+ subtype breast cancer ctDNA TZ68; {"isolate": "ctDNA, early breast cancer, Luminal B her2+, TZ68", "age": "55", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal A subtype breast cancer ctDNA TZ10; {"isolate": "ctDNA, advanced breast cancer, Luminal A, TZ10", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ9; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ9", "age": "34", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ12; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ12", "age": "67", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ15; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ15", "age": "53", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced bilateral subtype breast cancer ctDNA TZ76; {"isolate": "ctDNA, advanced breast cancer, bilateral, TZ76", "age": "56", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ19; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ19", "age": "45", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early unknown subtype breast cancer ctDNA TZ16; {"isolate": "ctDNA, early breast cancer, Unknown, TZ16", "age": "41", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced unknown subtype breast cancer ctDNA TZ17; {"isolate": "ctDNA, advanced breast cancer, Unknown, TZ17", "age": "74", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ24; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ24", "age": "61", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced unknown subtype breast cancer ctDNA TZ20; {"isolate": "ctDNA, advanced breast cancer, Unknown, TZ20", "age": "50", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2+ subtype breast cancer ctDNA TZ21; {"isolate": "ctDNA, early breast cancer, Luminal B her2+, TZ21", "age": "47", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ25; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ25", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ27; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ27", "age": "50", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early unknown subtype breast cancer ctDNA TZ78; {"isolate": "ctDNA, early breast cancer, Unknown, TZ78", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ63; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ63", "age": "49", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ38; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ38", "age": "34", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ37; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ37", "age": "60", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal A subtype breast cancer ctDNA TZ36; {"isolate": "ctDNA, advanced breast cancer, Luminal A, TZ36", "age": "53", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ34; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ34", "age": "37", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ33; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ33", "age": "58", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ32; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ32", "age": "57", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ31; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ31", "age": "62", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ30; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ30", "age": "45", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ29; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ29", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early TNBC subtype breast cancer ctDNA TZ28; {"isolate": "ctDNA, early breast cancer, TNBC, TZ28", "age": "50", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA TZ52; {"isolate": "ctDNA, early breast cancer, Luminal A, TZ52", "age": "39", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ51; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ51", "age": "45", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early TNBC subtype breast cancer ctDNA TZ71; {"isolate": "ctDNA, early breast cancer, TNBC, TZ71", "age": "30", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA TZ54; {"isolate": "ctDNA, early breast cancer, HER2, TZ54", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA XH9; {"isolate": "ctDNA, early breast cancer, Luminal A, XH9", "age": "40", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100027, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA XH12; {"isolate": "ctDNA, early breast cancer, Luminal A, XH12", "age": "51", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100030, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA XH4; {"isolate": "ctDNA, early breast cancer, Luminal A, XH4", "age": "75", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100023, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA XH5; {"isolate": "ctDNA, early breast cancer, HER2, XH5", "age": "46", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100024, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA XH6; {"isolate": "ctDNA, early breast cancer, HER2, XH6", "age": "54", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100025, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA XH8; {"isolate": "ctDNA, early breast cancer, Luminal A, XH8", "age": "47", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100026, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ49; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ49", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ50; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ50", "age": "37", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ75; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ75", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ145; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ145", "age": "68", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced HER2 subtype breast cancer ctDNA TZ146; {"isolate": "ctDNA, advanced breast cancer, HER2, TZ146", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ143; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ143", "age": "43", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ144; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ144", "age": "50", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ137; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ137", "age": "57", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ142; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ142", "age": "72", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ135; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ135", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2+ subtype breast cancer ctDNA TZ136; {"isolate": "ctDNA, early breast cancer, Luminal B her2+, TZ136", "age": "40", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal A subtype breast cancer ctDNA TZ132; {"isolate": "ctDNA, advanced breast cancer, Luminal A, TZ132", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ134; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ134", "age": "51", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ43; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ43", "age": "59", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2+ subtype breast cancer ctDNA XH2; {"isolate": "ctDNA, early breast cancer, Luminal B her2+, XH2", "age": "61", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100022, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA XH1; {"isolate": "ctDNA, early breast cancer, HER2, XH1", "age": "54", "biomaterial_provider": "National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ153; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ153", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ152; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ152", "age": "57", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA TZ151; {"isolate": "ctDNA, early breast cancer, HER2, TZ151", "age": "62", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2+ subtype breast cancer ctDNA TZ148; {"isolate": "ctDNA, early breast cancer, Luminal B her2+, TZ148", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced HER2 subtype breast cancer ctDNA TZ160; {"isolate": "ctDNA, advanced breast cancer, HER2, TZ160", "age": "63", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ158; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ158", "age": "44", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ155; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ155", "age": "49", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ154; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ154", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ57; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ57", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA TZ61; {"isolate": "ctDNA, early breast cancer, Luminal A, TZ61", "age": "48", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ59; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ59", "age": "53", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ53; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ53", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ127; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ127", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ125; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ125", "age": "43", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA TZ129; {"isolate": "ctDNA, early breast cancer, HER2, TZ129", "age": "54", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ116; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ116", "age": "67", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ114; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ114", "age": "33", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early HER2 subtype breast cancer ctDNA TZ121; {"isolate": "ctDNA, early breast cancer, HER2, TZ121", "age": "60", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal A subtype breast cancer ctDNA TZ120; {"isolate": "ctDNA, advanced breast cancer, Luminal A, TZ120", "age": "63", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ39; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ39", "age": "61", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ40; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ40", "age": "45", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early unknown subtype breast cancer ctDNA TZ41; {"isolate": "ctDNA, early breast cancer, Unknown, TZ41", "age": "38", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal A subtype breast cancer ctDNA TZ112; {"isolate": "ctDNA, advanced breast cancer, Luminal A, TZ112", "age": "52", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal B her2- subtype breast cancer ctDNA TZ113; {"isolate": "ctDNA, early breast cancer, Luminal B her2-, TZ113", "age": "61", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ48; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ48", "age": "47", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced TNBC subtype breast cancer ctDNA TZ42; {"isolate": "ctDNA, advanced breast cancer, TNBC, TZ42", "age": "37", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early TNBC subtype breast cancer ctDNA TZ66; {"isolate": "ctDNA, early breast cancer, TNBC, TZ66", "age": "65", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ64; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ64", "age": "53", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced unknown subtype breast cancer ctDNA TZ65; {"isolate": "ctDNA, advanced breast cancer, Unknown, TZ65", "age": "26", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early TNBC subtype breast cancer ctDNA TZ103; {"isolate": "ctDNA, early breast cancer, TNBC, TZ103", "age": "65", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced HER2 subtype breast cancer ctDNA TZ105; {"isolate": "ctDNA, advanced breast cancer, HER2, TZ105", "age": "42", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early Luminal A subtype breast cancer ctDNA TZ106; {"isolate": "ctDNA, early breast cancer, Luminal A, TZ106", "age": "45", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2+ subtype breast cancer ctDNA TZ107; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2+, TZ107", "age": "45", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of early TNBC subtype breast cancer ctDNA TZ108; {"isolate": "ctDNA, early breast cancer, TNBC, TZ108", "age": "61", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of advanced Luminal B her2- subtype breast cancer ctDNA TZ46; {"isolate": "ctDNA, advanced breast cancer, Luminal B her2-, TZ46", "age": "56", "biomaterial_provider": "Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin 300060, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0024; {"isolate": "ctDNA, health, N0024", "age": "65", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0021; {"isolate": "ctDNA, health, N0021", "age": "42", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0022; {"isolate": "ctDNA, health, N0022", "age": "40", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0014; {"isolate": "ctDNA, health, N0014", "age": "44", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0011; {"isolate": "ctDNA, health, N0011", "age": "58", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
title: WGBS of healthy human cfDNA N0012; {"isolate": "ctDNA, health, N0012", "age": "35", "biomaterial_provider": "Yingli Sun lab, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China", "sex": "female", "tissue": "plasma"}
Methods
All analysis was done using a bisulfite sequnecing data analysis
pipeline DNMTools
developed in the Smith lab at USC.
Mapping reads from bisulfite sequencing:
Bisulfite treated reads are mapped to the genomes with the
abismal
program. Input reads are
filtered by their quality, and adapter sequences in the 3' end of
reads are trimmed. This is done with cutadapt. Uniquely mapped reads
with mismatches/indels below given threshold are retained. For
pair-end reads, if the two mates overlap, the overlapping part of the
mate with lower quality is discarded. After mapping, we use the format
command in dnmtools to merge mates for paired-end reads. We use the
dnmtools uniq command to randomly select one from multiple reads
mapped exactly to the same location. Without random oligos as UMIs,
this is our best indication of PCR duplicates.
Estimating methylation levels:
After reads are mapped and filtered, the
dnmtools counts command is used to obtain read
coverage and estimate methylation levels at individual cytosine
sites. We count the number of methylated reads (those containing a
C) and the number of unmethylated reads (those containing a T) at
each nucleotide in a mapped read that corresponds to a cytosine in
the reference genome. The methylation level of that cytosine is
estimated as the ratio of methylated to total reads covering that
cytosine. For cytosines in the symmetric CpG sequence context,
reads from the both strands are collapsed to give a single
estimate. Very rarely do the levels differ between strands
(typically only if there has been a substitution, as in a somatic
mutation), and this approach gives a better estimate.
Bisulfite conversion rate:
The bisulfite conversion rate for an experiment is estimated with
the dnmtools bsrate command, which computes the
fraction of successfully converted nucleotides in reads (those
read out as Ts) among all nucleotides in the reads mapped that map
over cytosines in the reference genome. This is done either using
a spike-in (e.g., lambda), the mitochondrial DNA, or the nuclear
genome. In the latter case, only non-CpG sites are used. While
this latter approach can be impacted by non-CpG cytosine
methylation, in practice it never amounts to much.
Identifying hypomethylated regions (HMRs):
In most mammalian cells, the majority of the genome has high
methylation, and regions of low methylation are typically the
interesting features. (This seems to be true for essentially all
healthy differentiated cell types, but not cells of very early
embryogenesis, various germ cells and precursors, and placental
lineage cells.) These are valleys of low methylation are called
hypomethylated regions (HMR) for historical reasons. To identify
the HMRs, we use the dnmtools hmr command, which uses
a statistical model that accounts for both the methylation level
fluctations and the varying amounts of data available at each CpG
site.
Partially methylated domains:
Partially methylated domains are large genomic regions showing
partial methylation observed in immortalized cell lines and
cancerous cells. The pmd program is used to identify
PMDs.
Allele-specific methylation:
Allele-Specific methylated regions refers to regions where the
parental allele is differentially methylated compared to the
maternal allele. The program allelic is used to
compute allele-specific methylation score can be computed for each
CpG site by testing the linkage between methylation status of
adjacent reads, and the program amrfinder is used to
identify regions with allele-specific methylation.
For more detailed description of the methods of each step, please
refer to
the DNMTools
documentation.