ID:CD82_HUMAN DESCRIPTION: RecName: Full=CD82 antigen; AltName: Full=C33 antigen; AltName: Full=IA4; AltName: Full=Inducible membrane protein R2; AltName: Full=Metastasis suppressor Kangai-1; AltName: Full=Suppressor of tumorigenicity 6 protein; AltName: Full=Tetraspanin-27; Short=Tspan-27; AltName: CD_antigen=CD82; FUNCTION: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. SUBUNIT: Interacts directly with IGSF8. INTERACTION: Q8TAA9:VANGL1; NbExp=6; IntAct=EBI-682379, EBI-682393; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Lymphoid specific. SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CD82 CDC HuGE Published Literature: CD82 Positive Disease Associations: Anticoagulants Related Studies:
Anticoagulants Tiphaine Oudot-Mellakh et al. British journal of haematology 2012, Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project., British journal of haematology.
[PubMed 22443383]
MalaCards Disease Associations
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ModBase Predicted Comparative 3D Structure on P27701
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
