Human Gene CD82 (ENST00000342935.7_1) from GENCODE V48lift37
  Description: CD82 molecule, transcript variant 2 (from RefSeq NM_001024844.2)
Gencode Transcript: ENST00000342935.7_1
Gencode Gene: ENSG00000085117.13_13
Transcript (Including UTRs)
   Position: hg19 chr11:44,587,151-44,640,676 Size: 53,526 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr11:44,616,213-44,640,676 Size: 24,464 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2025-04-10 15:10:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:44,587,151-44,640,676)mRNA (may differ from genome)Protein (242 aa)
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UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CD82_HUMAN
DESCRIPTION: RecName: Full=CD82 antigen; AltName: Full=C33 antigen; AltName: Full=IA4; AltName: Full=Inducible membrane protein R2; AltName: Full=Metastasis suppressor Kangai-1; AltName: Full=Suppressor of tumorigenicity 6 protein; AltName: Full=Tetraspanin-27; Short=Tspan-27; AltName: CD_antigen=CD82;
FUNCTION: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
SUBUNIT: Interacts directly with IGSF8.
INTERACTION: Q8TAA9:VANGL1; NbExp=6; IntAct=EBI-682379, EBI-682393;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Lymphoid specific.
SIMILARITY: Belongs to the tetraspanin (TM4SF) family.

+  Genetic Association Studies of Complex Diseases and Disorders
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-  MalaCards Disease Associations
  MalaCards Gene Search: CD82
Diseases sorted by gene-association score: prostate cancer* (21), chromophobe renal cell carcinoma (3), bladder cancer, somatic (3)
* = Manually curated disease association

+  Comparative Toxicogenomics Database (CTD)
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-  Common Gene Haplotype Alleles
 
Generated from 1000 Genomes Phase1 variants (help). Note the association of SNP alleles within a haplotype is statistically imputed rather than directly observed in most cases.
Restricted to 1 non-synonymous, common variant site with a frequency of occurrence of at least 1%.
HaplotypeHomozygous Variant Sites
Freq %Freq %RefI
54.931.6  V
45.121.7refI

Common gene alleles shown: 2
  

+  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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+  Microarray Expression Data
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+  mRNA Secondary Structure of 3' and 5' UTRs
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000301 - Tetraspanin
IPR018499 - Tetraspanin/Peripherin
IPR018503 - Tetraspanin_CS
IPR008952 - Tetraspanin_EC2

Pfam Domains:
PF00335 - Tetraspanin family

SCOP Domains:
48652 - Tetraspanin

ModBase Predicted Comparative 3D Structure on P27701
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+  Orthologous Genes in Other Species
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+  Gene Ontology (GO) Annotations with Structured Vocabulary
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-  Descriptions from all associated GenBank mRNAs
  KJ897074 - Synthetic construct Homo sapiens clone ccsbBroadEn_06468 CD82 gene, encodes complete protein.
AK225708 - Homo sapiens mRNA for CD82 antigen isoform 1 variant, clone: TMS02331.
AK312677 - Homo sapiens cDNA, FLJ93070, highly similar to Homo sapiens kangai 1 (suppression of tumorigenicity 6, prostate;CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonaland antibody IA4)) (KAI1), mRNA.
AK225410 - Homo sapiens mRNA for CD82 antigen isoform 1 variant, clone: HRC08483.
S48196 - C33 antigen=type III integral membrane protein [human, T cell line MOLT-4, mRNA, 1624 nt].
U20770 - Human metastasis suppressor (KAI1) mRNA, complete cds.
X53795 - Human R2 mRNA for an inducible membrane protein.
BC000726 - Homo sapiens CD82 molecule, mRNA (cDNA clone MGC:1713 IMAGE:2959683), complete cds.
BC001821 - Homo sapiens CD82 molecule, mRNA (cDNA clone MGC:3696 IMAGE:2959683), complete cds.
CU674366 - Synthetic construct Homo sapiens gateway clone IMAGE:100018675 5' read CD82 mRNA.
AB463474 - Synthetic construct DNA, clone: pF1KB6363, Homo sapiens CD82 gene for CD82 molecule, without stop codon, in Flexi system.
CR407650 - Homo sapiens full open reading frame cDNA clone RZPDo834G062D for gene KAI1, kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA complete cds, without stopcodon.
BT019761 - Homo sapiens kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) mRNA, complete cds.
BT019762 - Homo sapiens kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) mRNA, complete cds.
DQ892302 - Synthetic construct clone IMAGE:100004932; FLH185029.01X; RZPDo839E06146D CD82 molecule (CD82) gene, encodes complete protein.
DQ895501 - Synthetic construct Homo sapiens clone IMAGE:100009961; FLH185025.01L; RZPDo839E06145D CD82 molecule (CD82) gene, encodes complete protein.
AY303776 - Homo sapiens kangai 1 (KAI1) mRNA, complete cds; alternatively spliced.
CR542255 - Homo sapiens full open reading frame cDNA clone RZPDo834C0726D for gene KAI1, kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and ant; complete cds, incl. stopcodon.

+  Other Names for This Gene
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+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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